The Collaborative Research Center

1066

The organizational structure of the Collaborative Research Center 1066 reflects the different scientific disciplines as well as its numerous participating scientific institutions .

The spokesperson Prof. Dr. Stephan Grabbe (Department of Dermatology, University Medical Center Mainz) is supported on the board by Prof. Dr. Katharina Landfester (Max Planck Institute for Polymer Research) and Prof Dr. Pol Besenius (Department of Chemistry, JGU Mainz). Further representatives of medicine are Prof. Dr. Dr. Detlef Schuppan and Dr. Mustafa Diken (TRON). Dr. Lutz Nuhn (Max Planck Institute for Polymer Research) represents the young scientists on the board.

 

The Collaborative Research Center (CRC)1066 investigates the use of nanoparticular drug carriers (NP) in tumor immunotherapy. Novel polymer- and lipid-based NPs are synthesized, chemically characterized, and their application in complex biological systems up to humans is investigated. The aim is to activate the immune system of tumor patients in such a way that tumors are recognized and destroyed by the body's own immune defense system. In addition to a tumor-specific immune response by vaccination, we aim in particular at an immune reactivation of suppressed immune responses and a targeted modulation of the tumor microenvironment. Since both the selectivity and the nature of a desired immune response must be precisely controllable, requirements arise for therapeutic interventions in the immune system that cannot be met in this way by conventional small molecules as active agents. This is precisely where the potential of nanoparticulate drug carriers arises. Due to their complex - but chemically modifiable - structure, they can

(1) enclose active ingredients in such a way that they are protected against untargeted release or premature destruction, thus enabling the use of fragile or even toxic active ingredients (e.g. RNA, immunomodulators), 

(2) transport multiple drugs simultaneously, which is often mandatory for therapeutic interventions in the immune system, and

(3) they can be modified by surface functionalization so that they bind specifically to certain structures on cells or tissue and only develop their pharmacological effect there.

The CRC1066 reflects the growing importance of two modern research fields by applying the increasing power of nanomedicine to pressing problems in tumor immunotherapy, which is also highly dynamic. Central research fields here are:

  • Synthesis, complex functionalization and loading of nanoparticulate drug carriers.
  • Investigation of the fundamentals of the interaction of NP with biological media (blood, cell surfaces) and their distribution in the body
  • Analysis of the effect of multi-functionalized NPs on different leukocyte populations as well as on the immune system as a whole
  • Investigation of the principle applicability of NP as tumor immunotherapeutics, up to first clinical studies in humans.

This task can only be accomplished by the highly interdisciplinary setup of the CRC1066. Our focus has systematically evolved over two successful funding periods from NP synthesis to their characterization, functionalization, and application in living organisms. Building on this, we will now extensively test NP-based tumor immunotherapies in vivo and evaluate their clinical applicability.

 

To get a first insight into our research, our PhD students have produced entertaining and informative videos, which you are welcome to watch here

Speaker & Steering committee

Speaker

Prof. Dr. Stephan Grabbe

Universitätsmedizin (UM) der Johannes Gutenberg-Universität (JGU)
Hautklinik und Poliklinik
Langenbeckstraße 1
55131 Mainz
Tel.: 06131-17-2910

Sprecher emeritus und Berater

Prof. Dr. Rudolf Zentel

Institut für Organische Chemie
Fachbereich 09
Duesbergweg 10-14
55099 Mainz
Tel +49 6131 39-20361

Deputy Speaker

Prof. Dr. Katharina Landfester

Max-Planck-Institut für Polymerforschung
Ackermannweg 10
55128 Mainz
Tel +49 6131 379-170

Prof. Dr. Pol Besenius

Department Chemie
Duesbergweg 10- 14
55128 Mainz
Tel.: 06131-39-22355

Further representatives of the subprojects

Prof. Dr. Dr. Detlef Schuppan

Projektbereich B
Institut für Translationale Immunologie
Universitätsmedizin Mainz
Langenbeckstrasse 1
55131 Mainz
Tel +49 6131 17-7356

Dr. Mustafa Diken

Projektbereich Q
Translationale Onkologie an der Universitätsmedizin Mainz
Freiligrathstraße 12
55131 Mainz
Tel.: 06131-2161485

Representative of the young scientists

Dr. Lutz Nuhn

Max-Planck-Institut für Polymerforschung
Ackermannweg 10
55128 Mainz
Tel.: 06131- 379-311

Yanira Zeyn

Studentensprecherin des Graduiertenkollegs
Universitätsmedizin der Johannes Gutenberg-Universität Mainz
PKZI Geb. 308a
D-55131 Mainz

Tel +49 6131 17-9758

Scientific activity coordinators

Dr. Mareike Deuker

Koordinatorin des SFB 1066
Universitätsmedizin der Johannes Gutenberg-Universität Mainz
Max-Planck-Institut für Polymerforschung
Ackermannweg 10
D-55131 Mainz
Tel +49 6131 379-571

 

Yanira Zeyn

Studentensprecherin des Graduiertenkollegs
Universitätsmedizin der Johannes Gutenberg-Universität Mainz
PKZI Geb. 308a
D-55131 Mainz

Tel +49 6131 17-9758

Administration

Pia Neuhaus

Universitätsmedizin der Johannes Gutenberg-Universität Mainz
Hautklinik und Poliklinik
Geb. 401
Langenbeckstr.1
D-55131 Mainz
Tel  +49 6131 17-2545