Publikationen 2017

Microarray Analysis of Antibodies Induced with Synthetic Antitumor Vaccines: Specificity against Diverse Mucin Core Structures

Pett, C.; Cai, H.; Liu, J.; Palitzsch, B.; Schorlemer, M.; Hartmann, S.; Stergiou, N.; Lu, M.; Kunz, H.; Schmitt, E.; Westerlind, U.

Chem. – A Eur. J. 2017, 23 (16), 3875–3884

Transcutaneous Immunization with a Novel Imiquimod Nanoemulsion Induces Superior T Cell Responses and Virus Protection

Lopez, P. A.; Denny, M.; Hartmann, A. K.; Alflen, A.; Probst, H. C.; von Stebut, E.; Tenzer, S.; Schild, H.; Stassen, M.; Langguth, P.; Radsak, M. P.

J. Dermatol. Sci. 2017, 87 (3), 252–259

Programmable Assembly of Peptide Amphiphile via Noncovalent-to-Covalent Bond Conversion

Sato, K.; Ji, W.; Palmer, L. C.; Weber, B.; Barz, M.; Stupp, S. I.

J. Am. Chem. Soc. 2017, 139 (26), 8995–9000

JIF

Polymeric Selectin Ligands Mimicking Complex Carbohydrates: From Selectin Binders to Modifiers of Macrophage Migration

Moog, K. E.; Barz, M.; Bartneck, M.; Beceren-Braun, F.; Mohr, N.; Wu, Z.; Braun, L.; Dernedde, J.; Liehn, E. A.; Tacke, F.; Lammers, T.; Kunz, H.; Zentel, R.

Angew. Chemie – Int. Ed. 2017, 56 (5), 1416–1421

JIF

Personalized RNA Mutanome Vaccines Mobilize Poly-Specific Therapeutic Immunity against Cancer

Sahin, U.; Derhovanessian, E.; Miller, M.; Kloke, B. P.; Simon, P.; Löwer, M.; Bukur, V.; Tadmor, A. D.; Luxemburger, U.; Schrörs, B.; Omokoko, T.; Vormehr, M.; Albrecht, C.; Paruzynski, A.; Kuhn, A. N.; Buck, J.; Heesch, S.; Schreeb, K. H.; Müller, F.; Ortseifer, I.; Vogler, I.; Godehardt, E.; Attig, S.; Rae, R.; Breitkreuz, A.; Tolliver, C.; Suchan, M.; Martic, G.; Hohberger, A.; Sorn, P.; Diekmann, J.; Ciesla, J.; Waksmann, O.; Brück, A. K.; Witt, M.; Zillgen, M.; Rothermel, A.; Kasemann, B.; Langer, D.; Bolte, S.; Diken, M.; Kreiter, S.; Nemecek, R.; Gebhardt, C.; Grabbe, S.; Höller, C.; Utikal, J.; Huber, C.; Loquai, C.; Türeci, Ö.

Nature 2017, 547 (7662), 222–226

JIF

Size Tunable Core Crosslinked Micelles from HPMA-Based Amphiphilic Block Copolymers

Kramer, S.; Kim, K. O.; Zentel, R

Macromol. Chem. Phys. 2017, 218 (19), 1700113

Pharmacological and Physical Vessel Modulation Strategies to Improve EPR-Mediated Drug Targeting to Tumors

Ojha, T.; Pathak, V.; Shi, Y.; Hennink, W. E.; Moonen, C. T. W.; Storm, G.; Kiessling, F.; Lammers, T.

Adv. Drug Deliv. Rev. 2017, 119, 44–60

JIF

Secondary-Structure-Driven Self-Assembly of Reactive Polypept(o)ides: Controlling Size,Shape,and Function of Core Cross-Linked Nanostructures

Kristina Klinker ,Olga Schäfer, David Huesmann, Tobias Bauer, Leon Capelôa, Lydia Braun, Natascha Stergiou, Meike Schinnerer, Anjaneyulu Dirisala, Kanjiro Miyata, Kensuke Osada, Horacio Cabral, Kazunori Kataoka, Matthias Barz

Angew. Chem. Int. Ed. 56, 9608–9613 (2017)

JIF

Novel Concept of CD4-Mediated Activation of Regulatory T Cells for the Treatment of Graft-versus-Host Disease

Schlöder, J.; Berges, C.; Tuettenberg, A.; Jonuleit, H.

Front. Immunol. 2017, 8 (NOV)

Immunomodulatory Therapy of Inflammatory Liver Disease Using Selectin-Binding Glycopolymers

Matthias Bartneck1§, Christopher Thorsten Schlößer1§, Matthias Barz2, Rudolf Zentel2, Christian Trautwein1, Twan Lammers3, Frank Tacke1

ACS Nano (2017)

JIF

Surface Modification of Polysaccharide-Based Nanoparticles with PEG and Dextran and the Effects on Immune Cell Binding and Stimulatory Characteristics

Bamberger, D.; Hobernik, D.; Konhäuser, M.; Bros, M.; Wich, P. R.

Mol. Pharm. 2017, 14 (12), 4403–4416

Reciprocal Regulation of the Il9 Locus by Counteracting Activities of Transcription Factors IRF1 and IRF4

Carrascosa, L. C.; Klein, M.; Kitagawa, Y.; Lückel, C.; Marini, F.; König, A.; Guralnik, A.; Raifer, H.; Hagner-Benes, S.; Rädler, D.; Böck, A.; Kang, C.; Lohoff, M.; Garn, H.; Schaub, B.; Berberich-Siebelt, F.; Sakaguchi, S.; Bopp, T.; Huber, M.

Nat. Commun. 2017, 8

Balancing Passive and Active Targeting to Different Tumor Compartments Using Riboflavin-Functionalized Polymeric Nanocarriers

Y Tsvetkova, N Beztsinna, M Baues, D Klein, A Rix, SK Golombek, Wa’el Al Rawashdeh, Felix Gremse, Matthias Barz, Kaloian Koynov, Srinivas Banala, Wiltrud Lederle, Twan Lammers, Fabian Kiessling.

Nano Letters 17 (8), 4665-4674 (2017)

JIF

Polymere Selectinliganden Als Komplexe Glykomimetika: Von Selectinbindung Bis Zur Modifizierung Der Makrophagenmigration

Moog, K. E.; Barz, M.; Bartneck, M.; Beceren-Braun, F.; Mohr, N.; Wu, Z.; Braun, L.; Dernedde, J.; Liehn, E. A.; Tacke, F.; Lammers, T.; Kunz, H.; Zentel, R.

Angew. Chemie 2017, 129 (5), 1438–1443

Evaluation of FASP, SP3, and IST Protocols for Proteomic Sample Preparation in the Low Microgram Range

Sielaff, M.; Kuharev, J.; Bohn, T.; Hahlbrock, J.; Bopp, T.; Tenzer, S.; Distler, U.

J. Proteome Res. 2017, 16 (11), 4060–4072

Acid-Labile Surfactants Based on Poly(Ethyleneglycol), Carbon Dioxide and Propylene Oxide: Miniemulsion Polymerization and Degradation Studies

Scharfenberg, M.; Wald, S.; Wurm, F. R.; Frey, H.

Polymers (Basel). 2017, 9 (9)

Tuning the PH-Switch of Supramolecular Polymer Carriers for SiRNA to Physiologically Relevant PH

Ahlers, P.; Frisch, H.; Holm, R.; Spitzer, D.; Barz, M.; Besenius, P.

Macromol. Biosci. 2017, 17 (10)

Cationic Nanohydrogel Particles for Therapeutic Oligonucleotide Delivery

Leber, N.; Nuhn, L.; Zentel, R.

Macromol. Biosci. 2017, 17 (10), 1700092

Dimethyl Fumarate Therapy Significantly Improves the Responsiveness of T Cells in Multiple Sclerosis Patients for Immunoregulation by Regulatory T Cells

Schlöder, J.; Berges, C.; Luessi, F.; Jonuleit, H.

Int. J. Mol. Sci. 2017, 18 (2)

Amphiphilic Ferrocene-Containing PEG Block Copolymers as Micellar Nanocarriers and Smart Surfactants

Alkan, A.; Wald, S.; Louage, B.; De Geest, B. G.; Landfester, K.; Wurm, F. R.

Langmuir 2017, 33 (1), 272–279

Modulation of Mitochondriotropic Properties of Cyanine Dyes by in Organello Copper-Free Click Reaction

Negwer, I.; Hirsch, M.; Kaloyanova, S.; Brown, T.; Peneva, K.; Butt, H. J.; Koynov, K.; Helm, M.

ChemBioChem 2017, 18 (18), 1814–1818

Reversible Covalent and Supramolecular Functionalization of Water-Soluble Gold(I) Complexes

Kemper, B.; von Gröning, M.; Lewe, V.; Spitzer, D.; Otremba, T.; Stergiou, N.; Schollmeyer, D.; Schmitt, E.; Ravoo, B. J.; Besenius, P.

Chem. – A Eur. J. 2017, 23 (25), 6048–6055

Combined Immunotherapy: CTLA-4 Blockade Potentiates Anti-Tumor Response Induced by Transcutaneous Immunization

Rausch, J.; Lopez, P. A.; Bialojan, A.; Denny, M.; Langguth, P.; Probst, H. C.; Schild, H.; Radsak, M. P.

J. Dermatol. Sci. 2017, 87 (3), 300–306

Magnetism of Monomer MnO and Heterodimer FePt@MnO Nanoparticles

Sun, X.; Klapper, A.; Su, Y.; Nemkovski, K.; Wildes, A.; Bauer, H.; Köhler, O.; Schilmann, A.; Tremel, W.; Petracic, O.; Brückel, T.

Phys. Rev. B 2017, 95 (13), 134427

Pd@Fe2O3 Superparticles with Enhanced Peroxidase Activity by Solution Phase Epitaxial Growth

Kluenker, M.; Nawaz Tahir, M.; Ragg, R.; Korschelt, K.; Simon, P.; Gorelik, T. E.; Barton, B.; Shylin, S. I.; Panthöfer, M.; Herzberger, J.; Frey, H.; Ksenofontov, V.; Möller, A.; Kolb, U.; Grin, J.; Tremel, W.

Chem. Mater. 2017, 29 (3), 1134–1146

Immunization with a Synthetic Human MUC1 Glycopeptide Vaccine against Tumor-Associated MUC1 Breaks Tolerance in Human MUC1 Transgenic Mice

Stergiou, N.; Glaffig, M.; Jonuleit, H.; Schmitt, E.; Kunz, H.

ChemMedChem 2017, 12 (17), 1424–1428

One-Pot Synthesis to Quinone-Based Diaza[3.3]Cyclophanes

Stahlhofen, J. M.; Schollmeyer, D.; Waldvogel, S. R.

European J. Org. Chem. 2017, 2017 (48), 7226–7230

The Good and the Bad Collagens of Fibrosis – Their Role in Signaling and Organ Function

Karsdal, M. A.; Nielsen, S. H.; Leeming, D. J.; Langholm, L. L.; Nielsen, M. J.; Manon-Jensen, T.; Siebuhr, A.; Gudmann, N. S.; Rønnow, S.; Sand, J. M.; Daniels, S. J.; Mortensen, J. H.; Schuppan, D.

Adv. Drug Deliv. Rev. 2017, 121, 43–56

From Polymers to Functional Biomaterials

Weil, T.; Barz, M.

Macromol. Biosci. 2017, 17 (10), 1700307

Potassium Triggers a Reversible Specific Stiffness Transition of Polyethylene Glycol

Tüting, L.; Ye, W.; Settanni, G.; Schmid, F.; Wolf, B. A.; Ahijado-Guzmán, R.; Sönnichsen, C.

J. Phys. Chem. C 2017, 121 (40), 22396–22402

A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development

Boege, Y.; Malehmir, M.; Healy, M. E.; Bettermann, K.; Lorentzen, A.; Vucur, M.; Ahuja, A. K.; Böhm, F.; Mertens, J. C.; Shimizu, Y.; Frick, L.; Remouchamps, C.; Mutreja, K.; Kähne, T.; Sundaravinayagam, D.; Wolf, M. J.; Rehrauer, H.; Koppe, C.; Speicher, T.; Padrissa-Altés, S.; Maire, R.; Schattenberg, J. M.; Jeong, J. S.; Liu, L.; Zwirner, S.; Boger, R.; Hüser, N.; Davis, R. J.; Müllhaupt, B.; Moch, H.; Schulze-Bergkamen, H.; Clavien, P. A.; Werner, S.; Borsig, L.; Luther, S. A.; Jost, P. J.; Weinlich, R.; Unger, K.; Behrens, A.; Hillert, L.; Dillon, C.; Di Virgilio, M.; Wallach, D.; Dejardin, E.; Zender, L.; Naumann, M.; Walczak, H.; Green, D. R.; Lopes, M.; Lavrik, I.; Luedde, T.; Heikenwalder, M.; Weber, A.

Cancer Cell 2017, 32 (3), 342-359.e10

Acrylamides with Hydrolytically Labile Carbonate Ester Side Chains as Versatile Building Blocks for Well-Defined Block Copolymer Micelles via RAFT Polymerization

Kasmi, S.; Louage, B.; Nuhn, L.; Verstraete, G.; Van Herck, S.; Van Steenbergen, M. J.; Vervaet, C.; Hennink, W. E.; De Geest, B. G.

Polym. Chem. 2017, 8 (42), 6544–6557

Validation of Weak Biological Effects by Round Robin Experiments: Cytotoxicity/Biocompatibility of SiO2 and Polymer Nanoparticles in HepG2 Cells

Landgraf, L.; Nordmeyer, D.; Schmiel, P.; Gao, Q.; Ritz, S.; Gebauer, J. S.; Graß, S.; Diabaté, S.; Treuel, L.; Graf, C.; Rühl, E.; Landfester, K.; Mailänder, V.; Weiss, C.; Zellner, R.; Hilger, I.

Sci. Rep. 2017, 7 (1)

Amphiphilic Polysaccharide Block Copolymers for PH-Responsive Micellar Nanoparticles

Breitenbach, B. B.; Schmid, I.; Wich, P. R.

Biomacromolecules 2017, 18 (9), 2839–2848

Folding Induced Supramolecular Assembly into pH-Responsive Nanorods with a Protein Repellent Shell.

R. Otter, K. Klinker, D. Spitzer, M. Schinnerer, M. Barz, P. Besenius

Chem. Commun. (2017)

A Synthetic MUC1 Anticancer Vaccine Containing Mannose Ligands for Targeting Macrophages and Dendritic Cells

M. Glaffig, N. Stergiou, S. Hartmann, E. Schmitt, H. Kunz

ChemMedChem (2017)

Permanent magnet system to guide superparamagnetic particles

O. Baun, P. Blümler

Journal of Magnetism and Magnetic Materials 439, 294-304 (2017)

Silver Oxide Mediated Monotosylation of Poly(ethylene glycol) (PEG): Heterobifunctional PEG via Polymer Desymmetrization

H. Pohlit, M. Worm, J. Langhanki, E. Berger-Nicoletti, T. Opatz, H. Frey

Macromolecules (2017)

Morphology-Controlled Synthesis of Lignin Nanocarriers for Drug Delivery and Carbon Materials

D. Yiamsawas, S.J. Beckers, H. Lu, K. Landfester, F.R. Wurm

ACS Biomater. Sci. Eng. 3 (10), 2375-2383 (2017)

Polyglycerol Surfmers and Surfactants for Direct and Inverse Miniemulsion

S. Wald, J. Simon, J.P. Dietz, F.R. Wurm, K. Landfester

Macromol. Biosci. 17, 1700070 (2017)

Fully degradable protein nanocarriers by orthogonal photoclick tetrazole-ene chemistry for the encapsulation and release

K Piradashvili, J. Simon, D. Passlick, J.R. Hoehner, V. Mailaender, F.R. Wurm, K. Landfester

Nanoscale Horizons 2, 297-302 (2017)

Incorporation of mRNA in lamellar lipid matrices for parenteral administration

A. Ziller, S. S. Nogueira, E. Huehn, S. S. Funari, G. Brezesinski, H. Hartmann, U. Sahin, H. Haas, P. Langguth

Mol. Pharmaceutics (2017)

Upconversion Nanocarriers Encapsulated with Photoactivatable Ru Complexes for Near-Infrared Light-Regulated Enzyme Activity

Z. Chen, R. Thiramanas, M. Schwendy, C. Xie, S. H. Parekh, V. Mailänder, S. Wu

Small 13 (46), 1700997 (2017)

JIF

Photoactivation of Anticancer Ru Complexes in Deep Tissue: How Deep Can We Go?

W. Sun, R. Thiramanas, L. Slep, X. Zeng, V. Mailänder V, S. Wu S

Chem. Eur. J. 23,10832-10837 (2017)

Targeting myeloid cells in the tumor sustaining microenvironment

J. Schupp, F. K. Krebs, N. Zimmer, E. Trzeciak, D. Schuppan, A. Tuettenberg.

Cell Immunol. (2017)

Dendritic Mesoporous Silica Nanoparticles for pH-Stimuli-Responsive Drug Delivery of TNF-Alpha

A. Kienzle, S. Kurch, J. Schlöder, C. Berges, R. Ose, J. Schupp, A. Tuettenberg, H. Weiss, J. Schultze, S. Winzen, M. Schinnerer, K. Koynov, M. Mezger, N. K. Haass, W. Tremel, H. Jonuleit.

Adv Health Mat. (2017)

Optimized Solid-Phase-Assisted Synthesis of Oleic Acid Containing siRNA Nanocarriers

Sören Reinhard, Wei Zhang, and Ernst Wagner

ChemMedChem 12, 1464 – 1470 (2017)

EGFR Targeting and Shielding of pDNA Lipopolyplexes via Bivalent Attachment of a Sequence-Defined PEG Agent

Stephan Morys, Sarah Urnauer, Christine Spitzweg, and Ernst Wagner

Macromol. Biosci. 2017, 1700203

Minicircle Versus Plasmid DNA Delivery by Receptor-Targeted Polyplexes

Ana Krhac Levacic, Stephan Morys, Susanne Kempter, Ulrich Lächelt, and Ernst Wagner

Human Gene Ther. 28 (10), (2017)

Combining reactive triblock copolymers with functional crosslinkers: A versatile pathway to disulfide stabilized-polyplex libraries and their application as pDNA vaccines

Philipp Heller, Dominika Hobernik, Ulrich Lächelt, Meike Schinnerer, Benjamin Weber, Manfred Schmidt, Ernst Wagner, Matthias Bros, and Matthias Barz

J. Control. Release 258, 146-160 (2017).

Visualization of the protein corona: towards a biomolecular understanding of nanoparticle cell- interactions

M. Kokkinopoulou, J. Simon, K. Landfester, V. Mailänder, I. Lieberwirth

Nanoscale 9, 8858-8870 (2017)

Sequence-Controlled Delivery of Peptides from Hierarchically Structured Nanomaterials

C.W. He, M. Parowatkin, V. Mailander, M. Flechtner-Mors, U. Ziener, K. Landfester, D. Crespy

ACS Appl. Mater. Interf., 9, 3885-3894 (2017)

Coating nanoparticles with tunable surfactants facilitates control over the protein corona

J. Müller, K.N. Bauer, D. Prozeller, J. Simon, V. Mailander, F.R. Wurm, S. Winzen, K. Landfester

Biomaterials 115, 1-8 (2017).

JIF

Protein corona composition of poly(ethylene glycol)- and poly(phosphoester)-coated nanoparticles correlates strongly with the amino acid composition of the protein surface

G. Settanni, J.J. Zhou, T.C. Suo, S. Schöttler, K. Landfester, F. Schmid, V. Mailänder

Nanoscale 9, 2138-2144 (2017).

Functional Colloidal Stabilization

A.C. Bijlard, S. Wald, D. Crespy, A. Taden, F.R. Wurm, K. Landfester

Advanced Material Interfaces 4, 1600443 (2017)

Permeability of Polymer Nanocapsules

I. Schlegel, R. Munoz-Espi, I. Lieberwirth, G. Floudas, Y. Suzuki, D. Crespy, K. LandfesterCrystallinity Tunes

Macromolecules 50, 4725-4732 (2017)

"Clickable PEG” via anionic copolymerization of ethylene oxide and glycidyl propargyl ether

J. Herzberger, D. Leibig, J. Langhanki, C. Moers, T. Opatz, H. Frey,

Polym. Chem. 2017, 8

Bioconjugation of Small Molecules to RNA Impedes Its Recognition by Toll-Like Receptor

Hellmuth, I., Freund, I., Schlöder, J., Seidu-Larry, S., Thüring, K., Slama, K., Langhanki, J., Kaloyanova, S., Eigenbrod, T., Krumb, M., Röhm, S., Peneva K., Opatz, T., Jonuleit, H., Dalpke, A.H., Helm, M.,

(2017), 7. Fronti. Immunol., Mar. 24, 8:312,

PeptoSomes for Vaccination: Combining Antigen and Adjuvant in Polypept(o)ide-Based Polymersomes

Weber, B., Kappel, C., Scherer, M., Helm, M., Bros. M., Grabbe, S., Barz, M.

(2017), Macromol Biosci., Jul. 31, Epub ahead of print

The influence of block ionomer microstructure on polyplex properties: Can simulations help to understand differences in transfection efficiency?

P. Heller, B. Weber, J. Zhou, D. Hobernik, M. Bros, F. Schmid, M. Barz,

Small 13, 1603694 (2017).

JIF

Endocytotic uptake of HPMA-based polymers by different cancer cells: impact of extracellular acidosis and hypoxia

Daniel Gündel, Mareli Allmeroth, Sarah Reime, Rudolf Zentel, Oliver Thews

International Journal of Nanomedicine 12, 5571–5584 (2017)

Block copolymers from ionic liquids for the preparation of thin carbonaceous shells

Sadaf Hanif, Bernd Oschmann, Dmitri Spetter, Muhammad Nawaz Tahir, Wolfgang Tremel and Rudolf Zentel*

Beilstein J. Org. Chem. 13, 1693-1701 (2917),

Combining Orthogonal Reactive Groups in Block Copolymers for Functional Nanoparticle Synthesis in a Single Step

Olga Schäfer, Kristina Klinker, Lydia Braun, David Huesmann, Jennifer Schultze, Kaloian Koynov, and Matthias Barz

ACS Macro Lett, (2017)

Synthesis and Characterization of Stimuli-Responsive Star-Like Polypept(o)ides: Introducing Biodegradable PeptoStars

Regina Holm, Benjamin Weber, Philipp Heller, Kristina Klinker, Dana Westmeier, Dominic Docter, Roland H. Stauber, Matthias Barz

Macromol. Biosci. 17, 1600514 (2017)

Evidence for pleural epithelial-mesenchymal transition in murine compensatory lung growth

Ysasi, Alexandra B; Wagner, Willi L; Valenzuela, Cristian D; Kienzle, Arne; Servais, Andrew B; Bennett, Robert D; Tsuda, Akira; Ackermann, Maximilian; Mentzer, Steven J.

PLoS One. 12(5), e0177921 (2017)

Tissue Engineering Part A

Servais, Andrew; Kienzle, Arne; Valenzuela, Cristian D; Ysasi, Alexandra B; Wagner, Willi L; Tsuda, Akira; Ackermann, Maximilian; Mentzer, Steven J.

Advanced Healthcare Materials. 6(13), 2192-2659 (2017)

SiRNA-mediated In Vivo Gene Knockdown by Acid-Degradable Cationic Nanohydrogel Particles

Nadine Leber,⁺ Leonard Kaps,⁺ Misbah Aslam, Jonathan Schupp, Alexander Brose, David Schäffel, Karl Fischer, Mustafa Diken, Dennis Strand, Kaloian Koynov, Andrea Tuettenberg, Lutz Nuhn,* Rudolf Zentel,* Detlef Schuppan*

J. Controlled Release 248, 10–23 (2017)

Targeting distinct myeloid cell populations in vivo using polymers, liposomes and microbubbles

Can Ergen, Felix Heymann, Wa’el Al Rawashdeh, Felix Gremse, Matthias Bartneck, Ulf Panzer, Robert Pola, Michal Pechar, Gert Storm, Nicole Mohr, Matthias Barz, Rudolf Zentel, Fabian Kiessling, Christian Trautwein, Twan Lammers*, Frank Tacke*

Biomaterials 114, 106–120 (2017)