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Publications 2021

In-Depth Immune-Oncology Studies of the Tumor Microenvironment in a Humanized Melanoma Mouse Model

Jonathan Schupp, Arne Christians, Niklas Zimmer, Lukas Gleue, Helmut Jonuleit, Mark Helm, Andrea Tuettenberg

Int. J. Mol. Sci. Jan 2021, 22(3), 1011; https://doi.org/10.3390/ijms22031011

 

Immune signature as predictive marker for response to checkpoint inhibitor immunotherapy and overall survival in melanoma

Franziska K. Krebs, Emily R. Trzeciak, Sophia Zimmer, Deniz Özistanbullu, Heidrun Mitze Rink, Markus Meissner, Stephan Grabbe, Carmen Loquai, Andrea Tuettenberg

Biomaterials Science Jan 2021, DOI: 10.1002/cam4.3710 

 

 

Functional inhibition of Oct leads to HNF4α upregulation

Vollmar J, Kim YO, Marquardt JU, Galle PR, Schuppan D, Zimmermann T.

Exp Ther Med. 2021

Apr;21(4):349. doi: 10.3892/etm.2021.9780. Epub 2021 Feb 11. PMID: 33732322;

PMCID: PMC7903485.

 

Self-immolative RAFT-polymer endgroup modification

Maximilian Scherger, Hansjoachim Räder, Lutz Nuhn

Macromolecular Rapid Communication Feb 25 2021, DOI:10.1002/marc.202000752.

Sterilizing Immunity against SARS-CoV-2 Infection in Mice by a Single- Shot and Lipid Amphiphile Imidazoquinoline TLR7/8 Agonist-Adjuvanted Recombinant Spike Protein Vaccine

Sonia Jangra, Jana De Vrieze, Angela Choi, Raveen Rathnasinghe, Gabriel Laghlali, Annemiek Uvyn, Simon Van Herck, Lutz Nuhn, Kim Deswarte, Zifu Zhong, Niek N. Sanders, Stefan Lienenklaus, Sunil David, Shirin Strohmeier, Fatima Amanat, Florian Krammer, Hamida Hammad, Bart N. Lambrecht, Lynda Coughlan, Adolfo García-Sastre, Bruno G. De Geest, Michael Schotsaert

Angewandte Chemie International Edition Mar 11 2021, DOI:10.1002/anie.202015362; Angewandte Chemie 2021, DOI:10.1002/ange.202015362

Targeted Repolarization of Tumor-associated Macrophages via Imidazoquinoline-linked Nanobodies

Evangelia Bolli, Maximilian Scherger, Sana M. Arnouk, Ana Rita Pombo Antunes, David Straßburger, Moritz Urschbach, Judith Stickdorn, Karen De Vlaminck, Kiavash Movahedi, Hans Joachim Räder, Sophie Hernot, Pol Besenius, Jo A. Van Ginderachter, Lutz Nuhn

Advanced Science Mar 08 2021, DOI: 10.1002/advs.202004574

Iodine-124 PET quantification of organ-specific delivery and expression of NIS-encoding RNA

Miederer M, Pektor S, Miederer I, Bausbacher N, Keil IS, Hefesha H, Haas H, Sahin U, Diken M. 

EJNMMI Res. 2021 Feb 10;11(1):14. doi: 10.1186/s13550-021-00753-2., PMID: 33569663

Alpha-1 antitrypsin inhibits TMPRSS2 protease activity and SARS-CoV-2 infection

Wettstein, L.; Weil, T.; Conzelmann, C.; Müller, J. A.; Groß, R.; Hirschenberger, M.; Seidel, A.; Klute, S.; Zech, F.; Prelli Bozzo, C.; Preising, N.; Fois, G.; Lochbaum, R.; Knaff, P. M.; Mailänder, V.; Ständker, L.; Thal, D. R.; Schumann, C.; Stenger, S.; Kleger, A.; Lochnit, G.; Mayer, B.; Ruiz-Blanco, Y. B.; Hoffmann, M.; Sparrer, K. M. J.; Pöhlmann, S.; Sanchez-Garcia, E.; Kirchhoff, F.; Frick, M.; Münch, J.

Nat. Commun. Mar 2021, 12(1):1726. doi: 10.1038/s41467-021-21972-0.

Mechanistic investigation of thermosensitive liposome immunogenicity and understanding the drivers for circulation half-life: A polyethylene glycol versus 1,2-dipalmitoyl-sn-glycero-3-phosphodiglycerol study

Lokerse, W. J. M.; Lazarian A.; Kleinhempel, A.; Petrini, M.; Schwarz, P.; Hossann, M.; Holdt, L. M.; Mailänder, V.; Lindner, L. H.

J Control Release. Mar 2021, 333:1-15. doi: 10.1016/j.jconrel.2021.03.014.

Heparin modulates the cellular uptake of nanomedicines

Champanhac, C.; Haas, H.; Landfester K.; Mailänder, V.

Biomater Sci. 2021 Feb 21, 9(4):1227-1231. doi: 10.1039/d0bm01946a.

Conformation of Polyethylene Glycol Determines the Stealth Effect of Nanocarriers in the Low Protein Adsorption Regime

Li, M.; Jiang, S.; Simon, J.; Paßlick, D.; Frey, M. L.; Wagner, M.; Mailänder, V.; Crespy, D.; Landfester, K. Brush

Nano Lett. Feb 2021, 21(4):1591-1598. doi: 10.1021/acs.nanolett.0c03756.

A paradigm shift in cancer nanomedicine: From traditional tumor targeting to leveraging the immune system

Sofias AM, Combes F, Koschmieder S, Storm G, Lammers T.

 Drug Discov Today Epub, doi: 10.1016/j.drudis.2021.02.017 (Feb 2021)

Lyophilization stabilizes clinical-stage core-crosslinked polymeric micelles to overcome cold chain supply challenges

Ojha T, Hu Q, Colombo C, Wit J, van Geijn M, van Steenbergen M, Bagheri M, Königs-Werner H, Buhl E, Bansal R, Shi Y, Hennink W, Storm G, Rijcken C, Lammers T.

Biotechnology Journal e2000212 (Jan 2021), https://doi.org/10.1002/biot.202000212

The Functional Crosstalk between Myeloid-Derived Suppressor Cells and Regulatory T Cells within the Immunosuppressive Tumor Microenvironment

Haist M, Stege H, Grabbe S, Bros M.

Cancers (Basel). 2021 Jan 8;13(2):210. doi: 10.3390/cancers13020210.

Immune signature as predictive marker for response to checkpoint inhibitor immunotherapy and overall survival in melanoma

Krebs FK, Trzeciak ER, Zimmer S, Özistanbullu D, Mitzel-Rink H, Meissner M, Grabbe S, Loquai C, Tuettenberg A.

Cancer Med. 2021 Mar;10(5):1562-1575. doi: 10.1002/cam4.3710

Complement-Opsonized Nano-Carriers Are Bound by Dendritic Cells (DC) via Complement Receptor (CR)3, and by B Cell Subpopulations via CR-1/2, and Affect the Activation of DC and B-1 Cells

Bednarczyk M, Medina-Montano C, Fittler FJ, Stege H, Roskamp M, Kuske M, Langer C, Vahldieck M, Montermann E, Tubbe I, Röhrig N, Dzionek A, Grabbe S, Bros M.

Int J Mol Sci. 2021 Mar 11;22(6):2869. doi: 10.3390/ijms22062869

Supramolecular polymerization of sulfated dendritic peptide amphiphiles into multivalent L-selectin binders

Strassburger, D., Herziger, S., Huth, K., Urschbach, M., Haag, R. and Besenius P.

Beilstein J Org Chem 17: 97-104 (2021)

Pi electron-stabilized polymeric micelles potentiate docetaxel therapy in advanced-stage gastrointestinal cancer

Liang, C., Bai, X., Qi, C., Sun, Q., Han, X., Lan, T., Zhang, H., Zheng, X., Liang, R., Jiao, J., Zheng, Z., Fang, J., Lei, P., Wang, Y., Möckel, D., Metselaar, J., Storm, G., Hennink, W.,   Kiessling, F., Wei, H., Lammers, T., Shi, Y. and Wie Bo.

Biomaterials 266: 120432 (2021)

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JIF

Roadmap on nanomedicine

Decuzzi, P., Peer, D., Di Mascolo, D., Palange, A., Manghnani, P., Moghimi, S., Farhangrazi, Z., Howard, K., Rosenblum, D., Liang, T., Chen, Z., Wang, Z., Zhu, J., Gu, Z., Korin., N, Letourneur, D., Chauvierre, C, van der Meel, R., Kiessling, F. and Lammers, T.

Nanotechnology 32(1): 012001 (2021)

Sterilizing Immunity against SARS-CoV-2 Infection in Mice by a Single-Shot and Lipid Amphiphile Imidazoquinoline TLR7/8 Agonist-Adjuvanted Recombinant Spike Protein Vaccine

Jangra, S., De Vrieze, J., Choi, A., Rathnasinghe, R., Laghlali, G., Uvyn, A, Van Herck, S., Nuhn, L., Deswarte, K., Zhong, Z., Sanders, N., Lienenklaus, S., David, S., Strohmeier, S, Amanat, F., Krammer,F., Hammad, H., Lambrecht, B., Coughlan L., Garcia Sastre, A., de Geest. and B., Schotsaert, M.

Angew Chem Int Ed Engl. (2021)

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JIF

Effect of Core-Crosslinking on Protein Corona Formation on Polymeric Micelles

Alberg, I., Kramer, S., Leps, C., Tenzer, S. and Zentel, R.

Macromol. Biosci. (2021)

Observation of interaction forces by investigation of the influence of eluent additives on the retention behavior of aqueous nanoparticle dispersions in asymmetrical flow field-flow fractionation

Nickel, C., Scherer, C., Noskov S., Bantz, C., Berger, M., Schupp, W. and Maskos, M.

J Chromatogr A 1637: 461840.(2021)

Influence of oscillating main flow on separation efficiency in asymmetrical flow field-flow fractionation

Berger, M., Scherer, C., Noskov, S., Bantz, C., Nickel, C., Schupp, W. and Maskos, M.

Journal of Chromatography A. (2021)

Heparin Modulates the Cellular Uptake of Nanomedicine

Champanhac, C., Haas, H., Landfester, K. and Mailänder, V.

Biomaterials Science (2021)

Unraveling the In Vivo Protein Corona

Simon, J., Kuhn, G., Fichter, M., Gehring, S., Landfester, K. and Mailänder, V.

Cells 10(1) (2021)

Insights into colloidal nanoparticle-protein corona interactions fornanomedicine applications

Martinez-Negro, M., Gonzalez-Rubio, G., Aicart, E., Landfester, K., Guerrero-Martinez, A. and Junquera, E.

Advances in Colloid and Interface Science 289  (2021)

Self-immolative RAFT-polymer end group modification

Scherger, M., Räder, H. and Nuhn, L.

Macromolecular Rapid Communication (2021)

Design of pH-Degradable Polymer-Lipid Amphiphiles Using a Ketal-Functionalized RAFT Chain Transfer Agent

De Vrieze, J., van Herck, S., Nuhn, L. and De Geest, Bruno

Macromol Rapid Commun 42(2): e2000696. (2021)

In-Depth Immune-Oncology Studies of the Tumor Microenvironment in a Humanized Melanoma Mouse Model

Schupp J, Christians A, Zimmer N, Gleue L, Jonuleit H, Helm M,  Tuettenberg A

Int J Mol Sci 2021, 22, 1011

Immune signature as predictive marker for response to checkpoint inhibitor immunotherapy and overall survival in melanoma

Krebs FK, Trzeciak E, Zimmer S, Oezistanbullu D, Mitzel-Rink H, Meissner M, Grabbe S, Loquai C, Tuettenberg A

Cancer Med. 2021.