Optimizing RNA Vaccines

The EMBL (European Molecular Biology Laboratory) and DESY (Deutsches Elektronen-Sychroton der Helmholtz-Gemeinschaft) recently reported on outstanding research results that were generated in cooperation with the CRC1066 and BioNTech, among others. They show ways how the development of better RNA vaccines can succeed through structure elucidation with state-of-the-art measuring instruments.


C. D. Siewert, et al.Hybrid Biopolymer and Lipid Nanoparticles with Improved Transfection Efficacy for mRNA. Cells 2020, 9(9), 2034

S. S. Nogueiraet al.Polysarcosine-Functionalized Lipid Nanoparticles for Therapeutic mRNA Delivery. ACS Appl. Nano Mater. 2020

L. Uebbinget al. Investigation of pH-Responsiveness inside Lipid Nanoparticles for Parenteral mRNA Application Using Small-Angle X‐ray Scattering. Langmuir 2020 36 (44), 13331-13341