Publikationen 2018
Tumor immunoevasion via acidosis-dependent induction of regulatory tumor-associated macrophages
T. Bohn, S. Rapp, N. Luther, M. Klein, TJ. Bruehl, N. Kojima, P. Aranda Lopez,
J. Hahlbrock, S. Muth, S. Endo, S. Pektor, A. Brand, K. Renner, V. Popp, K. Gerlach,
D. Vogel, C. Lueckel, D. Arnold-Schild, J. Pouyssegur, M. Kreutz, M. Huber, J. Koenig,
B. Weigmann, HC. Probst, E. von Stebut, B. Becker, H. Schild, E. Schmitt, T. Bopp
Nature Immunology 2018, 19, 1319–1329.
Pre-adsorption of antibodies enables targeting of nanocarriers despite a biomolecular corona
M. Tonigold, J. Simon, D. Estupinan, M. Kokkinopoulou, J. Reinholz, U. Kintzel, A. Kaltbeizel, P. Renz, M.P. Domogalla, K. Steinbrink, I. Lieberwirth, D. Crespy, K. Landfester, V. Mailänder
Nature Nanotech. 2018, 13, 862-869.
Nanoparticle-Conjugate TLR7/8 Agonist Localized Immunotherapy Provokes Safe Antitumoral Responses
L. Nuhn, S. De Koker, S. Van Lint, Z. Zhong, J. P. Catani, F. Combes, K. Deswarte, Y. Li, B. N. Lambrecht, S. Lienenklaus, N. N. Sanders, S. A. David, J. Tavernier, B. G. De Geest
Adv. Mater. 2018, 30, e1803397.
Potent Anti-Viral Vaccine Adjuvant Based on PH-Degradable Nanogels with Covalently Linked Small Molecule Imidazoquinoline TLR7/8 Agonist
L. Nuhn, L. Van Hoecke, K. Deswarte, B. Schepens, Y. Li, B. N. Lambrecht, S. De Koker, S. A. David, X. Saelens, B. G. De Geest
Biomaterials 2018, 178, 643–651.
Iron Oxide Superparticles with Enhanced MRI Performance by Solution Phase Epitaxial Growth
Kluenker, M.; Tahir, M. N.; Dören, R.; Deuker, M.; Komforth, P.; Plana-Ruiz, S.; Barton, B.; Shylin, S. I.; Ksenofontov, V.; Panthöfer, M.; Wiesmann, N.; Herzberger, J.; Möller, A.; Frey, H.; Brieger, J.; Kolb, U.; Tremel, W.
Chem. Mater. 2018, 30 (13), 4277–4288
Differentially Tolerized Mouse Antigen Presenting Cells Share a Common MiRNA Signature Including Enhanced Mmu-MiR-223-3p Expression Which Is Sufficient to Imprint a Protolerogenic State
Bros, M.; Youns, M.; Kollek, V.; Buchmüller, D.; Bollmann, F.; Seo, E. J.; Schupp, J.; Montermann, E.; Usanova, S.; Kleinert, H.; Efferth, T.; Reske-Kunz, A. B.
Front. Pharmacol. 2018, 9 (AUG), 915
Protein Corona–Mediated Targeting of Nanocarriers to B Cells Allows Redirection of Allergic Immune Responses
Shen, L.; Tenzer, S.; Storck, W.; Hobernik, D.; Raker, V. K.; Fischer, K.; Decker, S.; Dzionek, A.; Krauthäuser, S.; Diken, M.; Nikolaev, A.; Maxeiner, J.; Schuster, P.; Kappel, C.; Verschoor, A.; Schild, H.; Grabbe, S.; Bros, M.
J. Allergy Clin. Immunol. 2018, 142 (5), 1558–1570
Transiently Thermoresponsive Acetal Polymers for Safe and Effective Administration of Amphotericin B as a Vaccine Adjuvant
Van Herck, S.; Van Hoecke, L.; Louage, B.; Lybaert, L.; De Coen, R.; Kasmi, S.; Esser-Kahn, A. P.; David, S. A.; Nuhn, L.; Schepens, B.; Saelens, X.; De Geest, B. G.
Bioconjug. Chem. 2018, 29 (3), 748–760
Protein-Corona-by-Design in 2D: A Reliable Platform to Decode Bio–Nano Interactions for the Next-Generation Quality-by-Design Nanomedicines
Mei, K. C.; Ghazaryan, A.; Teoh, E. Z.; Summers, H. D.; Li, Y.; Ballesteros, B.; Piasecka, J.; Walters, A.; Hider, R. C.; Mailänder, V.; Al-Jamal, K. T.
Adv. Mater. 2018, 30 (40)
Engineering von Proteinen an Oberflächen: Von Komplementärer Charakterisierung Zu Materialoberflächen Mit Maßgeschneiderten Funktionen
Morsbach, S.; Gonella, G.; Mailänder, V.; Wegner, S.; Wu, S.; Weidner, T.; Berger, R.; Koynov, K.; Vollmer, D.; Encinas, N.; Kuan, S. L.; Bereau, T.; Kremer, K.; Weil, T.; Bonn, M.; Butt, H.-J.; Landfester, K.
Angew. Chemie 2018, 130 (39), 12806–12830
Self-Amplifying RNA Vaccines Give Equivalent Protection against Influenza to MRNA Vaccines but at Much Lower Doses
Vogel, A. B.; Lambert, L.; Kinnear, E.; Busse, D.; Erbar, S.; Reuter, K. C.; Wicke, L.; Perkovic, M.; Beissert, T.; Haas, H.; Reece, S. T.; Sahin, U.; Tregoning, J. S.
Mol. Ther. 2018, 26 (2), 446–455
From Single Molecules to Nanostructured Functional Materials: Formation of a Magnetic Foam Catalyzed by Pd@FexO Heterodimers
Nawaz Tahir, M.; Kluenker, M.; Natalio, F.; Barton, B.; Korschelt, K.; Shylin, S. I.; Panthöfer, M.; Ksenofontov, V.; Möller, A.; Kolb, U.; Tremel, W.
ACS Appl. Nano Mater. 2018, 1 (3), 1050–1057
Enhanced Protection of C57 BL/6 vs Balb/c Mice to Melanoma Liver Metastasis Is Mediated by NK Cells
Foerster, F.; Boegel, S.; Heck, R.; Pickert, G.; Rüssel, N.; Rosigkeit, S.; Bros, M.; Strobl, S.; Kaps, L.; Aslam, M.; Diken, M.; Castle, J.; Sahin, U.; Tuettenberg, A.; Bockamp, E.; Schuppan, D.
Oncoimmunology 2018, 7 (4), e1409929–e1409929
Inducible Knockdown of Procollagen I Protects Mice from Liver Fibrosis and Leads to Dysregulated Matrix Genes and Attenuated Inflammation
Molokanova, O.; Schönig, K.; Weng, S. Y.; Wang, X.; Bros, M.; Diken, M.; Ohngemach, S.; Karsdal, M.; Strand, D.; Nikolaev, A.; Eshkind, L.; Schuppan, D.
Matrix Biol. 2018, 66, 34–49
Lymph-Node-Targeted Immune Activation by Engineered Block Copolymer Amphiphiles−TLR7/8 Agonist Conjugates
S. Van Herck, K. Deswarte, L. Nuhn, Z. Zhong, J. P Catani, Y. Li, N. N. Sanders, S. Lienenklaus, S. De Koker, B. N. Lambrecht, S. A. David, B. G. De Geest
J. Am. Chem. Soc. 2018, 140, 14300-14307.
pH-Sensitive Hydrazone-Linked Doxorubicin Nanogels via Polymeric-Activated Ester Scaffolds: Synthesis, Assembly, and In Vitro and In Vivo Evaluation in Tumor-Bearing Zebrafish
A. Van Driessche, A. Kocere, H. Everaert, L. Nuhn, S. Van Herck, G. Griffiths, F. Fenaroli, B. G. De Geest
Chem. Mater. 2018, 30, 8587-8596.
Enhanced Permeability and Retention-like Extravasation of Nanoparticles from the Vasculature into Tuberculosis Granulomas in Zebrafish and Mouse Models
F. Fenaroli, U. Repnik, Y. Xu, K. Johann, S. Van Herck, P. Dey, F. M. Skjeldal, D. M. Frei, S. Bagherifam, A. Kocere, R. Haag, B. G. De Geest, M. Barz, D. G. Russell, G. Griffiths
ACS Nano 2018, 12 (8), 8646–8661.
Monitoring Translation Activity of MRNA-Loaded Nanoparticles in Mice
S. Rosigkeit, M. Meng, C. Grunwitz, P. Gomes, A. Kreft, N. Hayduk, R. Heck, G. Pickert, K. Ziegler, Y. Abassi, J. Röder, L. Kaps, F. Vascotto, T. Beissert, S. Witzel, A. Kuhn, M. Diken, S. Schuppan, U. Sahin, H. Haas, E. Bockamp
Mol. Pharm. 2018, 15 (9), 3909–3919.
Engineering Proteins at Interfaces: From Complementary Characterization to Material Surfaces with Designed Functions
S. Morsbach, G. Gonella, V. Mailänder, S. Wegner, S. Wu, T. Weidner, R. Berger, K. Koynov, D. Vollmer, N. Encinas, S.L. Kuan, T. Bereau, K. Kremer, T. Weil, M. Bonn, H.J. Butt, K. Landfester
Angew. Chem. Intern. Ed. 2018, 57, 12626 –12648.
Application of polymersomes engineered to target p32 protein for detection of small breast tumors in mice
L. Simón-Gracia, P. Scodeller, S. S. Fuentes, V. G. Vallejo, X. Ríos, E. San Sebastián, V. Sidorenko, D. Di Silvio, M. Suck, F. De Lorenzi, L. Y. Rizzo, S. von Stillfried, K. Kilk, T. Lammers, S. E. Moya, T. Teesalu, L. Simón-Gracia, P. Scodeller, S. Salazar Fuentes, V. Gómez Vallejo, X. Ríos, E. San Sebastián, V. Sidorenko, D. Di Silvio, M. Suck, F. De Lorenzi, L. Yokota Rizzo, S. von Stillfried, K. Kilk, T. Lammers, S. E. Moya, T. Teesalu
Oncotarget, 9, 18682 (2018)
Enhanced photoluminescence properties of a carbon dot system through surface interaction with polymeric nanoparticles
R. Momper, J. Steinbrecher, M. Dorn, I. Rörich, S. Bretschneider, M. Tonigold, C. Ramanan, S. Ritz, V. Mailänder, K. Landfester, M. Bannwarth
J Colloid Interface Sci 518, 11–20 (2018)