Publikationen 2021

Paper

Cover

Cover picture in ChemBioChem - Prof. Dr. Pol Besenius et al 2018

Cover Picture in Advanced Healthcare Materials - Kaps et al. 2015

Cover picture in Macromolecular Bioscience - Heller et al. 2015

Back cover in Macromolecular Rapid Communications - Nuhn et al. 2014

Cover picture in Marcomolecular Bioscience - Heller et al. 2014

Back cover picture in Macromolecular Bioscience - Schieferstein et al. 2014

Dual Stimuli-Responsive Dynamic Covalent Peptide Tags: Toward Sequence-Controlled Release in Tumor-like Microenvironments

Zegota MM, Müller MA, Lantzberg B, Kizilsavas G, Coelho JAS, Moscariello P, Martínez-Negro M, Morsbach S, Gois PMP, Wagner M, Ng DYW, Kuan SL and Weil T

J Am Chem Soc. 2021 Oct 20

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Cross-linkable Polyion Complex Micelles from Polypept(o)ide-based ABC-triblock Copolymers for siRNA Delivery

Capelôa L, Yazdi M, Zhang H, Chen X, Nie Y, Wagner E, Lächelt U and Barz M

Macromol Rapid Commun. 2021 Dec 30

Transferrin Receptor Targeted Polyplexes Completely Comprised of Sequence-Defined Components

Benli-Hoppe T, Göl Öztürk Ş, Öztürk Ö, Berger S, Wagner E and Yazdi M

Macromol Rapid Commun. 2021 Oct 29

Alpha-single chains of collagen type VI inhibit the fibrogenic effects of triple helical collagen VI in hepatic stellate cells

Freise C, Lee H, Chronowski C, Chan D, Cziomer J, Rühl M, Dagdelen T, Lösekann M, Erben U, Catic A, Tegge W, Schuppan D, Somasundaram R, Sahin E

PLoS One 2021 Sep 2

A human liver cell-based system modeling a clinical prognostic liver signature for therapeutic discovery

Crouchet E, Bandiera S, Fujiwara N, Li S, El Saghire H, Fernández-Vaquero M, Riedl T, Sun X, Hirschfield H, Jühling F, Zhu S, Roehlen N, Ponsolles C, Heydmann L, Saviano A, Qian T, Venkatesh A, Lupberger J, Verrier ER, Sojoodi M, Oudot MA, Duong FHT, Masia R, Wei L, Thumann C, Durand SC, González-Motos V, Heide D, Hetzer J, Nakagawa S, Ono A, Song WM, Higashi T, Sanchez R, Kim RS, Bian CB, Kiani K, Croonenborghs T, Subramanian A, Chung RT, Straub BK, Schuppan D, Ankavay M, Cocquerel L, Schaeffer E, Goossens N, Koh AP, Mahajan M, Nair VD, Gunasekaran G, Schwartz ME, Bardeesy N, Shalek AK, Rozenblatt-Rosen O, Regev A, Felli E, Pessaux P, Tanabe KK, Heikenwälder M, Schuster C, Pochet N, Zeisel MB, Fuchs BC, Hoshida Y and Baumert TF

Nat Commun. 2021 Sep 17

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A structurally engineered fatty acid, icosabutate, suppresses liver inflammation and fibrosis in NASH

Fraser DA, Wang X, Lund J, Nikolić N, Iruarrizaga-Lejarreta M, Skjaeret T, Alonso C, Kastelein JJP, Rustan AC, Kim YO and Schuppan D

J Hepatol. 2021 Dec 13

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pH-Dependent Behavior of Ionizable Cationic Lipids in mRNA-Carrying Lipoplexes Investigated by Molecular Dynamics Simulations

Settanni G, Brill W, Haas H and Schmid F

Macromol Rapid Commun. 2021 Dec 7

Assembly of pH-Responsive Antibody-Drug-Inspired Conjugates

Raabe M, Heck AJ, Führer S, Schauenburg D, Pieszka M, Wang T, Zegota MM, Nuhn L, Ng DYW, Kuan SL and Weil T

Macromol Biosci 2021 Nov 17

Density of Conjugated Antibody Determines the Extent of Fc Receptor Dependent Capture of Nanoparticles by Liver Sinusoidal Endothelial Cells

Kappel C, Seidl C, Medina-Montano C, Schinnerer M, Alberg I, Leps C, Sohl J, Hartmann AK, Fichter M, Kuske M, Schunke J, Kuhn G, Tubbe I, Paßlick D, Hobernik D, Bent R, Haas K, Montermann E, Walzer K, Diken M, Schmidt M, Zentel R, Nuhn L, Schild H, Tenzer S, Mailänder V, Barz M, Bros M and Grabbe S

ACS Nano 2021 Sep 28

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Lipid Nature and Alkyl Length Influence Lymph Node Accumulation of Lipid-Polyethylene Glycol Amphiphiles

De Vrieze, J., Baptista, A.P., Nuhn, L., Van Herck, S., Deswarte, K., Yu, H., Lambrecht, B.N. and De Geest, B.G

Adv. Therap 2021

Novel Biodegradable Composite of Calcium Phosphate Cement and the Collagen I Mimetic P-15 for Pedicle Screw Augmentation in Osteoporotic Bone

Krenzlin H, Foelger A, Mailänder V, Blase C, Brockmann M, Düber C, Ringel F and Keric N

Biomedicines 2021 Oct 4

Transparent polycarbonate coated with CeO2 nanozymes repel Pseudomonas aeruginosa PA14 biofilms

Jegel O, Pfitzner F, Gazanis A, Oberländer J, Pütz E, Lange M, von der Au M, Meermann B, Mailänder V, Klasen A, Heermann R and Tremel W

Nanoscale 2021 Dec 23

Temperature-Responsive Nanoparticles Enable Specific Binding of Apolipoproteins from Human Plasma

Prawatborisut M, Oberländer J, Jiang S, Graf R, Avlasevich Y, Morsbach S, Crespy D, Mailänder V and Landfester K

Small 2021 Nov 10

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Modulating Protein Corona and Materials–Cell Interactions with Temperature‐Responsive Materials

M. Prawatborisut, S. Jiang, J. Oberländer, V. Mailänder, D. Crespy and K. Landfester

Adv. Funct. Mater 2021

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Controlling the semi-permeability of protein nanocapsules influences the cellular response to macromolecular payloads

Machtakova M, Wirsching S, Gehring S, Landfester K and Thérien-Aubin H

J Mater Chem B 2021 Oct 20

Strategies to Maximize Anthracycline Drug Loading in Albumin Microbubbles

Liu M, Dasgupta A, Qu N, Rama E, Kiessling F and Lammers T

ACS Biomater Sci Eng 2021 Dec 21

Intravenous pegylated liposomal prednisolone outperforms intramuscular methylprednisolone in treating rheumatoid arthritis flares: A randomized controlled clinical trial

Metselaar JM, Middelink LM, Wortel CH, Bos R, van Laar JM, Vonkeman HE, Westhovens R, Lammers T, Yao SL, Kothekar M, Raut A and Bijlsma JWJ

J Control Release 2021 Dec 10

Nanoparticles for Cancer Diagnosis, Radionuclide Therapy and Theranostics

Llop J and Lammers T

ACS Nano 2021 Nov 8

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Therapeutic melanoma inhibition by local micelle-mediated cyclic nucleotide repression

Johann K, Bohn T, Shahneh F, Luther N, Birke A, Jaurich H, Helm M, Klein M, Raker VK, Bopp T, Barz M and Becker C

Nat Commun. 2021 Oct 13;12(1):5981

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RAFT Synthesis of Reactive Multifunctional Triblock-Copolymers for Polyplex Formation

N. Ritt, A. Ayaou and R. Zentel

Macromol. Chem. Phys. 2100122, online (2021); DOI: 10.1002/macp.202100122

Polymer cyclization for the emergence of hierarchical nanostructures

Chen, C., Singh, M. K.; Wunderlich, K.; Harvey, S.; Whitfield, C., Zhou, Z.; Wagner, M.; Landfester, K.; Lieberwirth, I.; Fytas, G.; Kremer, K., Mukherji, D.; Ng, D. Y. W., Weil, T

Nature Communications 2021 doi.org/10.1038/s41467-021-24222-5

Squaric Ester-Based, pH-Degradable Nanogels: Modular Nanocarriers for Safe, Systemic Administration of Toll-Like Receptor 7/8 Agonistic Immune Modulators

A. Huppertsberg, L. Kaps, Z. Zhong, S. Schmitt, J. Stickdorn, K. Deswarte, F. Combes, C. Czysch, J. De Vrieze, S. Kasmi, N. Choteschovsky, A. Klefenz, C. Medina-Montano, P. Winterwerber, C. Chen, M. Bros, S. Lienenklaus, N. N. Sanders, K. Koynov, D. Schuppan, B. N. Lambrecht, S. David, B. G. De Geest, L. Nuhn

Journal of the American Chemical Society 2021, DOI: 10.1021/jacs.1c03772

Contactless Nanoparticle-Based Guiding of Cells by Controllable Magnetic Fields

Blümler, P.; Friedrich, R. P.; Pereira, J.; Baun, O.; Alexiou, C.; Mailänder, V

Nanotechnol Sci Appl. 2021, 14:91-100

Self-sustaining enzyme nanocapsules perform on-site chemical reactions

Machtakova, S. Han, Y. Yangazoglu, I. Lieberwirth, H. Therien-Aubin, K. Landfester

Nanoscale 2021, 13, 4051-4059

Brush Conformation of Polyethylene Glycol Determines the Stealth Effect of Nanocarriers in the Low Protein Adsorption Regime

M. Li, S. Jiang, J. Simon, D. Passlick, M.L. Frey, M. Wagner, V. Mailänder, D. Crespy, K. Landfester

Nano Letters 2021, 21, 1591-1598

The conjugation strategy affects antibody orientation and targeting properties of nanocarriers

M. Brueckner, J. Simon, K. Landfester, V. MailaenderS.M. Jo, F.R. Wurm, K. Landfester

Nanoscale 2021, 13, 9816-9824

Enzyme-Loaded Nanoreactors Enable the Continuous Regeneration of Nicotinamide Adenine Dinucleotide in Artificial Metabolisms

S.M. Jo, F.R. Wurm, K. Landfester

Angew. Chem. Intern. Ed. 2021, 60, 7728-7734

Applicability and safety of discontinuous ADVanced Organ Support (ADVOS) in the treatment of patients with acute-on-chronic liver failure (ACLF) outside of intensive care

L. Kaps, C. J. Ahlbrand, R. Gadban, M. Nagel, C. Labenz, P. Klimpke, S. Holtz, S. Boedecker, M. Michel, W. M. Kremer, M. Hilscher, P. R. Galle, D. Kraus, J. M. Schattenberg, J. Weinmann-Menke

PLoSOne. 2021 Apr 1;16(4):e0249342. doi: 10.1371/journal.pone.0249342

Factors accelerating recurrences and secondary tumors in cutaneous squamous cell carcinoma

Rahimi-Nedjat RK, Tuettenberg A, Sagheb K, Loquai C, Rybczynski B, Grabbe S, Walter C, Al-Nawas B

J Craniomaxillofac Surg. 2021 Apr;49(4):317-322. doi: 10.1016/j.jcms.2021.02.009

Response durability after cessation of immune checkpoint inhibitors in patients with metastatic Merkel cell carcinoma: a retrospective multicenter DeCOG study

Stege HM, Haist M, Schultheis S, Fleischer MI, Mohr P, Ugurel S, Terheyden P, Thiem A, Kiecker F, Leiter U, Becker JC, Meissner M, Kleeman J, Pföhler C, Hassel J, Grabbe S, Loquai C

Cancer Immunol Immunother. 2021 Apr 18. doi: 10.1007/s00262-021-02925-4

In-Depth Immune-Oncology Studies of the Tumor Microenvironment in a Humanized Melanoma Mouse Model

Jonathan Schupp, Arne Christians, Niklas Zimmer, Lukas Gleue, Helmut Jonuleit, Mark Helm, Andrea Tuettenberg

Int. J. Mol. Sci. Jan 2021, 22(3), 1011; https://doi.org/10.3390/ijms22031011

Immune signature as predictive marker for response to checkpoint inhibitor immunotherapy and overall survival in melanoma

Franziska K. Krebs, Emily R. Trzeciak, Sophia Zimmer, Deniz Özistanbullu, Heidrun Mitze Rink, Markus Meissner, Stephan Grabbe, Carmen Loquai, Andrea Tuettenberg

Biomaterials Science Jan 2021, DOI: 10.1002/cam4.3710

Functional inhibition of Oct leads to HNF4α upregulation

Vollmar J, Kim YO, Marquardt JU, Galle PR, Schuppan D, Zimmermann T.

Exp Ther Med. 2021

Apr;21(4):349. doi: 10.3892/etm.2021.9780. Epub 2021 Feb 11. PMID: 33732322;

PMCID: PMC7903485.

Self-immolative RAFT-polymer endgroup modification

Maximilian Scherger, Hansjoachim Räder, Lutz Nuhn

Macromolecular Rapid Communication Feb 25 2021, DOI:10.1002/marc.202000752.

Sterilizing Immunity against SARS-CoV-2 Infection in Mice by a Single- Shot and Lipid Amphiphile Imidazoquinoline TLR7/8 Agonist-Adjuvanted Recombinant Spike Protein Vaccine

Sonia Jangra, Jana De Vrieze, Angela Choi, Raveen Rathnasinghe, Gabriel Laghlali, Annemiek Uvyn, Simon Van Herck, Lutz Nuhn, Kim Deswarte, Zifu Zhong, Niek N. Sanders, Stefan Lienenklaus, Sunil David, Shirin Strohmeier, Fatima Amanat, Florian Krammer, Hamida Hammad, Bart N. Lambrecht, Lynda Coughlan, Adolfo García-Sastre, Bruno G. De Geest, Michael Schotsaert

Angewandte Chemie International Edition Mar 11 2021, DOI:10.1002/anie.202015362; Angewandte Chemie 2021, DOI:10.1002/ange.202015362

Targeted Repolarization of Tumor-associated Macrophages via Imidazoquinoline-linked Nanobodies

Evangelia Bolli, Maximilian Scherger, Sana M. Arnouk, Ana Rita Pombo Antunes, David Straßburger, Moritz Urschbach, Judith Stickdorn, Karen De Vlaminck, Kiavash Movahedi, Hans Joachim Räder, Sophie Hernot, Pol Besenius, Jo A. Van Ginderachter, Lutz Nuhn

Advanced Science Mar 08 2021, DOI: 10.1002/advs.202004574

Iodine-124 PET quantification of organ-specific delivery and expression of NIS-encoding RNA

Miederer M, Pektor S, Miederer I, Bausbacher N, Keil IS, Hefesha H, Haas H, Sahin U, Diken M.

EJNMMI Res. 2021 Feb 10;11(1):14. doi: 10.1186/s13550-021-00753-2., PMID: 33569663

Alpha-1 antitrypsin inhibits TMPRSS2 protease activity and SARS-CoV-2 infection

Wettstein, L.; Weil, T.; Conzelmann, C.; Müller, J. A.; Groß, R.; Hirschenberger, M.; Seidel, A.; Klute, S.; Zech, F.; Prelli Bozzo, C.; Preising, N.; Fois, G.; Lochbaum, R.; Knaff, P. M.; Mailänder, V.; Ständker, L.; Thal, D. R.; Schumann, C.; Stenger, S.; Kleger, A.; Lochnit, G.; Mayer, B.; Ruiz-Blanco, Y. B.; Hoffmann, M.; Sparrer, K. M. J.; Pöhlmann, S.; Sanchez-Garcia, E.; Kirchhoff, F.; Frick, M.; Münch, J.

Nat. Commun. Mar 2021, 12(1):1726. doi: 10.1038/s41467-021-21972-0.

Mechanistic investigation of thermosensitive liposome immunogenicity and understanding the drivers for circulation half-life: A polyethylene glycol versus 1,2-dipalmitoyl-sn-glycero-3-phosphodiglycerol study

Lokerse, W. J. M.; Lazarian A.; Kleinhempel, A.; Petrini, M.; Schwarz, P.; Hossann, M.; Holdt, L. M.; Mailänder, V.; Lindner, L. H.

J Control Release. Mar 2021, 333:1-15. doi: 10.1016/j.jconrel.2021.03.014.

Heparin modulates the cellular uptake of nanomedicines

Champanhac, C.; Haas, H.; Landfester K.; Mailänder, V.

Biomater Sci. 2021 Feb 21, 9(4):1227-1231. doi: 10.1039/d0bm01946a.

Conformation of Polyethylene Glycol Determines the Stealth Effect of Nanocarriers in the Low Protein Adsorption Regime

Li, M.; Jiang, S.; Simon, J.; Paßlick, D.; Frey, M. L.; Wagner, M.; Mailänder, V.; Crespy, D.; Landfester, K. Brush

Nano Lett. Feb 2021, 21(4):1591-1598. doi: 10.1021/acs.nanolett.0c03756.

A paradigm shift in cancer nanomedicine: From traditional tumor targeting to leveraging the immune system

Sofias AM, Combes F, Koschmieder S, Storm G, Lammers T.

Drug Discov Today Epub, doi: 10.1016/j.drudis.2021.02.017 (Feb 2021)

Lyophilization stabilizes clinical-stage core-crosslinked polymeric micelles to overcome cold chain supply challenges

Ojha T, Hu Q, Colombo C, Wit J, van Geijn M, van Steenbergen M, Bagheri M, Königs-Werner H, Buhl E, Bansal R, Shi Y, Hennink W, Storm G, Rijcken C, Lammers T.

Biotechnology Journal e2000212 (Jan 2021), https://doi.org/10.1002/biot.202000212

The Functional Crosstalk between Myeloid-Derived Suppressor Cells and Regulatory T Cells within the Immunosuppressive Tumor Microenvironment

Haist M, Stege H, Grabbe S, Bros M.

Cancers (Basel). 2021 Jan 8;13(2):210. doi: 10.3390/cancers13020210.

Immune signature as predictive marker for response to checkpoint inhibitor immunotherapy and overall survival in melanoma

Krebs FK, Trzeciak ER, Zimmer S, Özistanbullu D, Mitzel-Rink H, Meissner M, Grabbe S, Loquai C, Tuettenberg A.

Cancer Med. 2021 Mar;10(5):1562-1575. doi: 10.1002/cam4.3710

Complement-Opsonized Nano-Carriers Are Bound by Dendritic Cells (DC) via Complement Receptor (CR)3, and by B Cell Subpopulations via CR-1/2, and Affect the Activation of DC and B-1 Cells

Bednarczyk M, Medina-Montano C, Fittler FJ, Stege H, Roskamp M, Kuske M, Langer C, Vahldieck M, Montermann E, Tubbe I, Röhrig N, Dzionek A, Grabbe S, Bros M.

Int J Mol Sci. 2021 Mar 11;22(6):2869. doi: 10.3390/ijms22062869

Supramolecular polymerization of sulfated dendritic peptide amphiphiles into multivalent L-selectin binders

Strassburger, D., Herziger, S., Huth, K., Urschbach, M., Haag, R. and Besenius P.

Beilstein J Org Chem 17: 97-104 (2021)

Roadmap on nanomedicine

Decuzzi, P., Peer, D., Di Mascolo, D., Palange, A., Manghnani, P., Moghimi, S., Farhangrazi, Z., Howard, K., Rosenblum, D., Liang, T., Chen, Z., Wang, Z., Zhu, J., Gu, Z., Korin., N, Letourneur, D., Chauvierre, C, van der Meel, R., Kiessling, F. and Lammers, T.

Nanotechnology 32(1): 012001 (2021)

Pi electron-stabilized polymeric micelles potentiate docetaxel therapy in advanced-stage gastrointestinal cancer

Liang, C., Bai, X., Qi, C., Sun, Q., Han, X., Lan, T., Zhang, H., Zheng, X., Liang, R., Jiao, J., Zheng, Z., Fang, J., Lei, P., Wang, Y., Möckel, D., Metselaar, J., Storm, G., Hennink, W., Kiessling, F., Wei, H., Lammers, T., Shi, Y. and Wie Bo.

Biomaterials 266: 120432 (2021)

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Sterilizing Immunity against SARS-CoV-2 Infection in Mice by a Single-Shot and Lipid Amphiphile Imidazoquinoline TLR7/8 Agonist-Adjuvanted Recombinant Spike Protein Vaccine

Jangra, S., De Vrieze, J., Choi, A., Rathnasinghe, R., Laghlali, G., Uvyn, A, Van Herck, S., Nuhn, L., Deswarte, K., Zhong, Z., Sanders, N., Lienenklaus, S., David, S., Strohmeier, S, Amanat, F., Krammer,F., Hammad, H., Lambrecht, B., Coughlan L., Garcia Sastre, A., de Geest. and B., Schotsaert, M.

Angew Chem Int Ed Engl. (2021)

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Effect of Core-Crosslinking on Protein Corona Formation on Polymeric Micelles

Alberg, I., Kramer, S., Leps, C., Tenzer, S. and Zentel, R.

Macromol. Biosci. (2021)

Observation of interaction forces by investigation of the influence of eluent additives on the retention behavior of aqueous nanoparticle dispersions in asymmetrical flow field-flow fractionation

Nickel, C., Scherer, C., Noskov S., Bantz, C., Berger, M., Schupp, W. and Maskos, M.

J Chromatogr A 1637: 461840.(2021)

Influence of oscillating main flow on separation efficiency in asymmetrical flow field-flow fractionation

Berger, M., Scherer, C., Noskov, S., Bantz, C., Nickel, C., Schupp, W. and Maskos, M.

Journal of Chromatography A. (2021)

Heparin Modulates the Cellular Uptake of Nanomedicine

Champanhac, C., Haas, H., Landfester, K. and Mailänder, V.

Biomaterials Science (2021)

Unraveling the In Vivo Protein Corona

Simon, J., Kuhn, G., Fichter, M., Gehring, S., Landfester, K. and Mailänder, V.

Cells 10(1) (2021)

Insights into colloidal nanoparticle-protein corona interactions fornanomedicine applications

Martinez-Negro, M., Gonzalez-Rubio, G., Aicart, E., Landfester, K., Guerrero-Martinez, A. and Junquera, E.

Advances in Colloid and Interface Science 289 (2021)

Self-immolative RAFT-polymer end group modification

Scherger, M., Räder, H. and Nuhn, L.

Macromolecular Rapid Communication (2021)

Design of pH-Degradable Polymer-Lipid Amphiphiles Using a Ketal-Functionalized RAFT Chain Transfer Agent

De Vrieze, J., van Herck, S., Nuhn, L. and De Geest, Bruno

Macromol Rapid Commun 42(2): e2000696. (2021)

In-Depth Immune-Oncology Studies of the Tumor Microenvironment in a Humanized Melanoma Mouse Model

Schupp J, Christians A, Zimmer N, Gleue L, Jonuleit H, Helm M, Tuettenberg A

Int J Mol Sci 2021, 22, 1011

Immune signature as predictive marker for response to checkpoint inhibitor immunotherapy and overall survival in melanoma

Krebs FK, Trzeciak E, Zimmer S, Oezistanbullu D, Mitzel-Rink H, Meissner M, Grabbe S, Loquai C, Tuettenberg A

Cancer Med. 2021.