Publikationen 2023

Paper

Cover

Cover picture in ChemBioChem - Prof. Dr. Pol Besenius et al 2018

Cover Picture in Advanced Healthcare Materials - Kaps et al. 2015

Cover picture in Macromolecular Bioscience - Heller et al. 2015

Back cover in Macromolecular Rapid Communications - Nuhn et al. 2014

Cover picture in Marcomolecular Bioscience - Heller et al. 2014

Back cover picture in Macromolecular Bioscience - Schieferstein et al. 2014

Efficient Self-Immolative RAFT End Group Modification for Macromolecular Immunodrug Delivery

Maximilian Scherger, Yannick A. Pilger, Judith Stickdorn, Patric Komforth, Sascha Schmitt, Kaloian Koynov, Hans-Joachim Räder, Lutz Nuhn

Biomacromolecules 2023, 24, 2380-2391.

Quality by Design (QbD) Approach for a Nanoparticulate Imiquimod Formulation as an Investigational Medicinal Product

Pielenhofer, J., S. L. Meiser, K. Gogoll, A.-M. Ciciliani, M. Denny, M. Klak, B. M. Lang, P. Staubach, S. Grabbe, H. Schild, M. P. Radsak, H. Spahn-Langguth, P. Langguth.

Pharmaceutics 2023;5:514.

GARP Regulates the Immune Capacity of a Human Autologous Platelet Concentrate

Trzeciak ER, Zimmer N, Kämmerer PW, Thiem D, Al-Nawas B, Tuettenberg A, Blatt S.

Biomedicines 2022 5;10(12):3136

MUC1 Glycopeptide Vaccine Modified with a GalNAc Glycocluster Targets the Macrophage Galactose C-type Lectin on Dendritic Cells to Elicit an Improved Humoral Response

A. Gabba, R. Attariya, S. Behren, C. Pett, J.C. van der Horst, H. Yurugi, J. Yu, M. Urschbach, J. Sabin, G. Birrane, E. Schmitt, S.J. van Vliet, P. Besenius, U. Westerlind, P.V. Murphy.

J. Am. Chem. Soc. 2023, 145, 24, 13027–13037

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Subnanomolar Cathepsin S Inhibitors with High Selectivity: Optimizing Covalent Reversible α-Fluorovinylsulfones and α-Sulfonates as Potential Immunomodulators in Cancer

Fuchs, N.; Meta, M.; Lantzberg, B.; Bros, M.; Kuan, S. L.; Weil, T.; Schirmeister T.

ChemMedChem 2023

Immunomodulation of neutrophil granulocyte functions by bacterial polyphosphates

Krenzlin, V., J. Schöche, S. Walachowski, C. Reinhardt, M. P. Radsak, M. Bosmann.

Eur J Immunol. 2023 May

Endosomal sorting results in a selective separation of the protein corona from nanoparticles

Han S, da Costa Marques R, Simon J, Kaltbeitzel A, Koynov K, Landfester K, Mailänder V, Lieberwirth I.

Nat Commun. 2023; 14: 295.

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Systematic modulation of the lipid composition enables the tuning of liposome cellular uptake

Mateos-Maroto A, Gai M, Brückner M, da Costa Marques R, Harley I, Simon J, Mailänder V, Morsbach S, Landfester K.

Acta Biomater. 2023 Mar 1;158:463-474.

Antibacterial Nanostructured Surfaces Modulate Protein Adsorption, Inflammatory Responses, and Fibrous Capsule Formation

Visalakshan RM, Bright R, Burzava ALS, Barker AJ, Simon J, Ninan N, Palms D, Wood J, Martínez-Negro M, Morsbach S, Mailänder V, Anderson PH, Brown T, Barker D, Landfester K, Vasilev K.

ACS Appl. Mater. Interfaces 2023, 15, 1, 220–235

A new methodology combining QCM-D and proteomic profiling enables characterization of protein adsorption on 2D surfaces

Martínez-Negro M, Oberländer J, Simon J, Mailänder V, Morsbach S, Landfester K.

J Colloid Interface Sci. 2023 Jan 15; 630 (Pt A): 965-972

Advanced Skin Antisepsis: Application of UVA-Cleavable Hydroxyethyl Starch Nanocapsules for Improved Eradication of Hair Follicle-Associated Microorganisms

Busch, A.M. Hanuschik, Y. Avlasevich, K. Darm, E.F. Hochheiser, C. Kohler, E.A.A. Idelevich, K. Becker, P. Rotsch, K. Landfester, M.E.E. Darvin, M. Meinke, C.M.M. Keck, A. Kramer, P. Zwicker

Pharmaceutics 2023, 15, Art. No. 609

Delivery of Immunostimulatory Cargos in Nanocarriers Enhances Anti-Tumoral Nanovaccine Efficacy

J. Schunke, V. Mailänder, K. Landfester, M. Fichter

Intern. J. Molecular Sci. 2023, 24, Art. No 12174

Anti-PEG antibodies enriched in the protein corona of PEGylated nanocarriers impact the cell uptake

M.F.S. Deuker, V. Mailaender, S. Morsbach, K. Landfester

Nanoscale Horiz., 2023,8, 1377-1385

Tumor-infiltrating CCR2+ inflammatory monocytes counteract specific immunotherapy

Bartneck, J. M., A.-K. Hartmann, L. Stein, D. Arnold-Schild, M. Klein, M. Stassen, F. Marini, J. Pielenhofer, S. L. Meiser, P. Langguth, M. Mack, S. Muth, H. C. Probst, H. Schild, M. P. Radsak.

Front. Immunol 2023;14.

Externalized histones fuel pulmonary fibrosis via a platelet-macrophage circuit of TGFβ1 and IL-27

Riehl, D. R., A. Sharma, J. Roewe, F. Murke, C. Ruppert, S. A. Eming, T. Bopp, H. Kleinert, Markus P. Radsak, G. Colucci, S. Subramaniam, C. Reinhardt, B. Giebel, I. Prinz, A. Guenther, D. Strand, M. Gunzer, A. Waisman, P. A. Ward, W. Ruf, K. Schäfer, M. Bosmann.

Proc. Nat. Acad. Sci. USA 2023. Vol. 120 No. 40

Optimized dithranol-imiquimod-based transcutaneous immunization enables tumor rejection

Hartmann, A.-K., J. Bartneck, J. Pielenhofer,S. L. Meiser, D. Arnold-Schild, M. Klein, M. Stassen, H. Schild, S. Muth, H.-C. Probst, P. Langguth,S. Grabbe, M. P. Radsak.

Front. Immunol 2023. 14

Cross-presenting Langerhans cells are required for the early reactivation of resident CD8+ memory T cells in the epidermis

Kamenjarin, N., Hodapp, K., F. Melchior, G. S. Harms, A.-K. Hartmann, J. Bartneck, S. Muth, V. K. Raker, C. Becker, A. Brand, B. E. Clausen, M. P. Radsak, H. Schild, H. C. Probst.

Proc. Nat. Acad. Sci. USA 2023;120

Artificial intelligence assists nanoparticles to enter solid tumours

Lutz Nuhn

Nature Nanotechnology 2023, 18, 550-551.

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Post-Polymerization Modifications to Prepare Biomedical Nanocarriers with Varying Internal Structures, their Properties and Impact on Protein Corona Formation

Johannes Kockelmann, Rudolf Zentel, Lutz Nuhn

Macromolecular Chemistry and Physics 2023, 224, 24

Quantitative size-resolved characterization of mRNA nanoparticles by in-line coupling of asymmetrical-flow field-flow fractionation with small angle X-ray scattering

Graewert, M.A., Wilhelmy, C., Bacic, T. et al.

Sci Rep 13, 15764 (2023).

Computational approaches to lipid-based nucleic acid delivery systems

Giovanni Settanni

Eur. Phys. J. E (2023 Dec 14) 46: 127

Polymerizable 2-Propionic-3-methylmaleic Anhydrides as a Macromolecular Carrier Platform for pH-Responsive Immunodrug Delivery

AG. Heck, J. Stickdorn, LJ. Rosenberger, M. Scherger, J. Woller, K. Eigen, M. Bros, S. Grabbe, L. Nuhn

J. Am. Chem. Soc. 2023, 145, 50, 27424–27436

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Polymeric materials for ultrasound imaging and therapy

Barmin RA, Moosavifar M, Dasgupta A, Herrmann A, Kiessling F, Pallares RM, Lammers T.

Chem Sci. 2023 Oct 17;14(43):11941-11954.

Transferrin Receptor-Targeted Nonspherical Microbubbles for Blood–Brain Barrier Sonopermeation

Dasgupta A, Sun T, Rama E, Motta A, Zhang Y, Power C, Moeckel D, Fletcher SM, Moosavifar M, Barmin R, Porte C, Buhl EM, Bastard C, Pallares RM, Kiessling F, McDannold N, Mitragotri S, Lammers T.

Adv Mater. 2023 Dec;35(52)

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Tunable polymeric micelles for taxane and corticosteroid co-delivery

Shalmani AA, Wang A, Ahmed Z, Sheybanifard M, Mihyar R, Buhl EM, Pohl M, Hennink WE, Kiessling F, Metselaar JM, Shi Y, Lammers T, Peña Q.

Drug Deliv Transl Res. 2023 Nov 14.

Macrophages and platelets in liver fibrosis and hepatocellular carcinoma

Casari M, Siegl D, Deppermann C, Schuppan D.

Front Immunol. 2023 Dec 5; 14: 1277808.

A New Synthetic Curcuminoid Displays Antitumor Activities in Metastasized Melanoma

Kaps L, Klefenz A, Traenckner H, Schneider P, Andronache I, Schobert R, Biersack B, Schuppan D.

Cells. 2023 Nov 13; 12(22): 2619.

Reversible Polymer–Protein Functionalization by Stepwise Introduction of Amine-Reactive, Reductive-Responsive Self-Immolative End Groups onto RAFT-Derived Polymers

Maximilian Scherger, Yannick A. Pilger, Patric Komforth, Hans-Joachim Räder, Lutz Nuhn

ACS Biomater. Sci. Eng. 2024, 10, 1, 129–138

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Sonderforschungsbereich 1066

Nanodimensionale polymere Therapeutika für die Tumortherapie gefördert seit 2013 durch die DFG