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Publikationen 2023

Quality by Design (QbD) Approach for a Nanoparticulate Imiquimod Formulation as an Investigational Medicinal Product

Pielenhofer, J., S. L. Meiser, K. Gogoll, A.-M. Ciciliani, M. Denny, M. Klak, B. M. Lang, P. Staubach, S. Grabbe, H. Schild, M. P. Radsak, H. Spahn-Langguth, P. Langguth

Pharmaceutics 2023, 15(2), 514

Immunomodulation of neutrophil granulocyte functions by bacterial polyphosphates

Viola Krenzlin, Johannes Schöche, Sarah Walachowski, Christoph Reinhardt, Markus P. Radsak, Markus Bosmann

Eur. J. Immunol., 53: 2250339.

Subnanomolar Cathepsin S Inhibitors with High Selectivity: Optimizing Covalent Reversible α-Fluorovinylsulfones and α-Sulfonates as Potential Immunomodulators in Cancer

Natalie Fuchs Mergim Meta Bellinda Lantzberg Dr. Matthias Bros Dr. Seah Ling Kuan Prof. Dr. Tanja Weil Prof. Dr. Tanja Schirmeister

ChemMedChem 2023, 18, e202300160

Endosomal sorting results in a selective separation of the protein corona from nanoparticles

Shen Han, Richard da Costa Marques, Johanna Simon, Anke Kaltbeitzel, Kaloian Koynov, Katharina Landfester, Volker Mailänder & Ingo Lieberwirth 

Nat Commun 14, 295 (2023)

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Systematic modulation of the lipid composition enables the tuning of liposome cellular uptake

Ana Mateos-Maroto, Meiyu Gai, Maximilian Brückner, Richard da Costa Marques, Iain Harley, Johanna Simon, Volker Mailänder, Svenja Morsbach, Katharina Landfester

Acta Biomater. 2023 Mar 1

Antibacterial Nanostructured Surfaces Modulate Protein Adsorption, Inflammatory Responses, and Fibrous Capsule Formation

Visalakshan RM, Bright R, Burzava ALS, Barker AJ, Simon J, Ninan N, Palms D, Wood J, Martínez-Negro M, Morsbach S, Mailänder V, Anderson PH, Brown T, Barker D, Landfester K, Vasilev K.

CS Appl. Mater. Interfaces 2023, 15, 1, 220–235

 

A new methodology combining QCM-D and proteomic profiling enables characterization of protein adsorption on 2D surfaces

Martínez-Negro M, Oberländer J, Simon J, Mailänder V, Morsbach S, Landfester K.

J Colloid Interface Sci. 2023 Jan 15; 630: 965-972

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Advanced Skin Antisepsis: Application of UVA-Cleavable Hydroxyethyl Starch Nanocapsules for Improved Eradication of Hair Follicle-Associated Microorganisms

Busch, A.M. Hanuschik, Y. Avlasevich, K. Darm, E.F. Hochheiser, C. Kohler, E.A.A. Idelevich, K. Becker, P. Rotsch, K. Landfester, M.E.E. Darvin, M. Meinke, C.M.M. Keck, A. Kramer, P. Zwicker

Pharmaceutics 2023 Feb; 15(2): 609.

Delivery of Immunostimulatory Cargos in Nanocarriers Enhances Anti-Tumoral Nanovaccine Efficacy

Schunke, V. Mailänder, K. Landfester, M. Fichter

Intern. J. Molecular Sci. 2023, 24, Art. No 12174

 

Anti-PEG antibodies enriched in the protein corona of PEGylated nanocarriers impact the cell uptake

M.F.S. Deuker, V. Mailaender, S. Morsbach, K. Landfester

Nanoscale Horiz., 2023,8, 1377-1385

 

Tumor-infiltrating CCR2+ inflammatory monocytes counteract specific immunotherapy

Bartneck, J. M., A.-K. Hartmann, L. Stein, D. Arnold-Schild, M. Klein, M. Stassen, F. Marini, J. Pielenhofer, S. L. Meiser, P. Langguth, M. Mack, S. Muth, H. C. Probst, H. SchildM. P. Radsak

Front. Immunol 2023;14

Externalized histones fuel pulmonary fibrosis via a platelet-macrophage circuit of TGFβ1 and IL-27

Riehl, D. R., A. Sharma, J. Roewe, F. Murke, C. Ruppert, S. A. Eming, T. Bopp, H. Kleinert, Markus P. Radsak, G. Colucci, S. Subramaniam, C. Reinhardt, B. Giebel, I. Prinz, A. Guenther, D. Strand, M. Gunzer, A. Waisman, P. A. Ward, W. Ruf, K. Schäfer, M. Bosmann

Proc. Nat. Acad. Sci. USA 2023

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Optimized dithranol-imiquimod-based transcutaneous immunization enables tumor rejection

Hartmann, A.-K., J. Bartneck, J. Pielenhofer, S. L. Meiser, D. Arnold-Schild, M. Klein, M. Stassen, H. Schild, S. Muth, H.-C. Probst, P. Langguth, S. Grabbe, M. P. Radsak

Front. Immunol 2023;14

Cross-presenting Langerhans cells are required for the early reactivation of resident CD8+ memory T cells in the epidermis

Kamenjarin, N., Hodapp, K., F. Melchior, G. S. Harms, A.-K. Hartmann, J. Bartneck, S. Muth, V. K. Raker, C. Becker, A. Brand, B. E. Clausen, M. P. Radsak, H. Schild, H. C. Probst

Proc. Nat. Acad. Sci. USA 2023

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Artificial intelligence assists nanoparticles to enter solid tumours

Lutz Nuhn

Nature Nanotechnology 2023, 18, 550-551

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Efficient Self-Immolative RAFT End Group Modification for Macromolecular Immunodrug Delivery

Maximilian Scherger, Yannick A. Pilger, Judith Stickdorn, Patric Komforth, Sascha Schmitt, Kaloian Koynov, Hans-Joachim Räder, Lutz Nuhn

Biomacromolecules 2023, 24, 5, 2380–2391

Reversible Polymer–Protein Functionalization by Stepwise Introduction of Amine-Reactive, Reductive-Responsive Self-Immolative End Groups onto RAFT-Derived Polymers

Maximilian Scherger, Yannick A. Pilger, Patric Komforth, Hans-Joachim Räder, Lutz Nuhn

ACS Biomater. Sci. Eng. 2024, 10, 1, 129–138

Post-Polymerization Modifications to Prepare Biomedical Nanocarriers with Varying Internal Structures, their Properties and Impact on Protein Corona Formation

Johannes KockelmannRudolf ZentelLutz Nuhn

Macromol. Chem. Phys. 2023, 224, 2300199.

Self-Immolative Nanobody-Cysteine Residue Modification for Controlled Immunodrug Delivery

Maximilian SchergerYannick A. PilgerJudith StickdornPatric KomforthSascha SchmittSana M. ArnoukEls LebeggeKaloian KoynovHans-Joachim RäderJo A. Van GinderachterLutz Nuhn

Advanced Therapeutics 2023

Quantitative size-resolved characterization of mRNA nanoparticles by in-line coupling of asymmetrical-flow field-flow fractionation with small angle X-ray scattering

Melissa A. Graewert, Christoph Wilhelmy, Tijana Bacic, Jens Schumacher, Clement Blanchet, Florian Meier, Roland Drexel, Roland Welz, Bastian Kolb, Kim Bartels, Thomas Nawroth, Thorsten Klein, Dmitri Svergun, Peter Langguth & Heinrich Haas 

Sci Rep 13, 15764 (2023)

GARP Regulates the Immune Capacity of a Human Autologous Platelet Concentrate

Trzeciak ER, Zimmer N, Kämmerer PW, Thiem D, Al-Nawas B, Tuettenberg A, Blatt S

Biomedicines 2022 5;10(12):3136

MUC1 Glycopeptide Vaccine Modified with a GalNAc Glycocluster Targets the Macrophage Galactose C-type Lectin on Dendritic Cells to Elicit an Improved Humoral Response

A. Gabba, R. Attariya, S. Behren, C. Pett, J.C. van der Horst, H. Yurugi, J. Yu, M. Urschbach, J. Sabin, G. Birrane, E. Schmitt, S.J. van Vliet, P. Besenius, U. Westerlind, P.V. Murphy, J.

J. Am. Chem. Soc. 2023, 145, 24, 13027–13037

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